Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
| ▸ | LATS1 | O95835 | 5/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201296 | 0.91 | LATS1 (0.52) | TGFBR1LATS1HPGDLMNAMAPT | |
| SCHEMBL14320793 | 0.85 | CLK1 (0.49) | TGFBR1LATS1ROCK2HPGDLMNA | |
| SCHEMBL6694913 | 0.85 | LATS1 (0.57) | TGFBR1LATS1ROCK2HPGDLMNA | |
| SCHEMBL22201395 | 0.84 | FGFR2 (0.55) | TGFBR1LATS1HPGDLMNAMAPT | |
| SCHEMBL13154697 | 0.82 | TGFBR1 (0.71) | TGFBR1ROCK2LMNAMAPTROCK1 | |
| SCHEMBL29395013 | 0.82 | TGFBR1 (0.71) | TGFBR1ROCK2LMNAMAPTROCK1 | |
| SCHEMBL22201393 | 0.82 | ABCG2 (0.55) | TGFBR1ROCK2MKNK1ABCG2 | |
| SCHEMBL22201442 | 0.81 | HPGD (0.64) | TGFBR1LATS1HPGDLMNAMAPT | |
| SCHEMBL3587569 | 0.81 | TGFBR1 (0.69) | TGFBR1ROCK2ROCK1PDE5AABCG2 | |
| SCHEMBL7535210 | 0.80 | EGFR (0.71) | MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |