Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.49 |
| ▸ | PRKCH | P24723 | 8/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 8/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.49 |
| ▸ | PRKCA | P17252 | 7/20 | 0.49 |
| ▸ | PRKCB | P05771 | 5/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LATS1 | O95835 | 1/20 | 0.46 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201257 | 0.88 | FGFR2 (0.62) | FGFR2FLT3PRKCHPRKCEPRKD1 | |
| SCHEMBL22201469 | 0.81 | FGFR2 (0.62) | FGFR2FLT3PRKCHPRKCEPRKD1 | |
| Akn-028 SCHEMBL1642669 | 0.79 | FGFR2 (1.00) | FGFR2FLT3PRKD1EGFRFLT1 | |
| Akn-028 SCHEMBL31060922 | 0.79 | FGFR2 (1.00) | FGFR2FLT3PRKD1EGFRFLT1 | |
| SCHEMBL22201395 | 0.78 | FGFR2 (0.55) | FGFR2FLT3PRKD1LATS1TGFBR1 | |
| SCHEMBL1641665 | 0.76 | FGFR2 (0.64) | FGFR2FLT3PRKCDPRKCHPRKCE | |
| SCHEMBL7655860 | 0.75 | PRKD1 (0.52) | FGFR2FLT3PRKD1MAOAMAOB | |
| SCHEMBL22803328 | 0.74 | FGFR2 (0.56) | FGFR2FLT3PRKD1MAOAMAOB | |
| SCHEMBL30302541 | 0.74 | FGFR2 (0.56) | FGFR2FLT3PRKD1MAOAMAOB | |
| SCHEMBL7535216 | 0.74 | EGFR (0.65) | FGFR2FLT3PRKD1EGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |