Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.86 |
| ▸ | PDE5A | O76074 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4843696 | 0.83 | PDE5A (0.83) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL22201451 | 0.80 | ABCG2 (0.56) | ABCG2PDE5AGBA1 | |
| SCHEMBL1085418 | 0.80 | PDE5A (1.00) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL27721053 | 0.78 | PDE5A (0.68) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL27721055 | 0.77 | PDE5A (0.76) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL15452624 | 0.75 | ABCG2 (0.65) | ABCG2PDE5ALMNAALDH1A1MAPT | |
| SCHEMBL1083856 | 0.73 | CYP2D6 (0.74) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL1083761 | 0.72 | HPGD (1.00) | ABCG2PDE5ALMNAALDH1A1HPGD | |
| SCHEMBL6000218 | 0.72 | ABCG2 (0.46) | ABCG2CYP3A4KMT2ATP53 | |
| SCHEMBL22201524 | 0.72 | LMNA (0.58) | ABCG2PDE5ALMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |