Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16038165 | 0.76 | ABCG2 (0.53) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL15253806 | 0.74 | ABCG2 (0.57) | HPGDALDH1A1ABCG2MAPTKDM4E | |
| SCHEMBL1083761 | 0.73 | HPGD (1.00) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL22201525 | 0.73 | LMNA (0.56) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL22201405 | 0.72 | LMNA (0.58) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL22201623 | 0.72 | ABCG2 (0.86) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL16039656 | 0.71 | MAPT (0.59) | LMNAHPGDALDH1A1POLBABCG2 | |
| SCHEMBL6308496 | 0.71 | KMT2A (0.43) | ALDH1A1GSK3BIGFBP3KMT2A | |
| SCHEMBL7280956 | 0.71 | ABCG2 (1.00) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL163563 | 0.70 | IGFBP3 (0.43) | ALDH1A1IGFBP3SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |