Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ACP1 | P24666 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277479 | 0.81 | PDE5A (1.00) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL3459468 | 0.80 | MAPK1 (0.82) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL6698790 | 0.80 | LATS1 (0.76) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL3460899 | 0.79 | TLR9 (0.81) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL3460213 | 0.79 | ACP1 (0.71) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL17799806 | 0.78 | SLC6A3 (0.77) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL22201643 | 0.78 | KDM4E (1.00) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL13252155 | 0.78 | PDE5A (0.83) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL1062736 | 0.78 | PDE5A (0.89) | PDE5APTGS1TBXAS1PTGS2KDM4E | |
| SCHEMBL3459768 | 0.77 | PDE5A (0.76) | PDE5APTGS1TBXAS1PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |