Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916990 | 0.93 | TGFBR1 (0.74) | TGFBR1PDE5ASMN1; SMN2LMNAMAPT | |
| SCHEMBL22201671 | 0.92 | ALDH1A1 (0.61) | TGFBR1ALDH1A1KDM4ERXFP1HPGD | |
| SCHEMBL13319624 | 0.85 | TGFBR1 (0.72) | TGFBR1SMN1; SMN2LMNAMAPTABCG2 | |
| SCHEMBL882807 | 0.85 | TGFBR1 (0.68) | TGFBR1KDM4ESMN1; SMN2MAPTABCG2 | |
| SCHEMBL22201673 | 0.84 | KDM1A (0.67) | TGFBR1ALDH1A1KDM4ERXFP1HPGD | |
| SCHEMBL14962717 | 0.83 | ABCG2 (0.70) | TGFBR1KDM4EHPGDPDE5ASMN1; SMN2 | |
| SCHEMBL16882618 | 0.82 | TGFBR1 (0.59) | TGFBR1POLBSMN1; SMN2LMNAMAPT | |
| SCHEMBL22201675 | 0.81 | ALDH1A1 (0.61) | TGFBR1ALDH1A1KDM4ERXFP1HPGD | |
| SCHEMBL22201447 | 0.80 | HPGD (0.70) | TGFBR1ALDH1A1KDM4ERXFP1HPGD | |
| SCHEMBL22201342 | 0.80 | HPGD (0.70) | TGFBR1ALDH1A1KDM4ERXFP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |