Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 4/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324315 | 0.82 | KDM4E (0.31) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL2764882 | 0.78 | KDM4E (0.50) | L3MBTL1TP53KDM4EALDH1A1MAPT | |
| SCHEMBL15845130 | 0.77 | PTGS1 (0.31) | — | |
| SCHEMBL8433568 | 0.76 | KDM4E (0.49) | L3MBTL1TP53KDM4EALDH1A1TBXA2R | |
| SCHEMBL10505153 | 0.76 | KDM4E (0.49) | L3MBTL1TP53KDM4EALDH1A1MAPT | |
| SCHEMBL3602796 | 0.76 | KDM4E (0.49) | L3MBTL1TP53KDM4EALDH1A1MAPT | |
| SCHEMBL11089825 | 0.76 | KDM4E (0.49) | L3MBTL1TP53KDM4EALDH1A1MAPT | |
| SCHEMBL11086697 | 0.76 | KDM4E (0.49) | L3MBTL1TP53KDM4EALDH1A1MAPT | |
| SCHEMBL6024211 | 0.75 | CYP2D6 (0.43) | POLBALDH1A1TDP1 | |
| SCHEMBL13652342 | 0.73 | NOS1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3680230-B1 | HYPOCRELLIN DERIVATIVE SUBSTITUTED BOTH IN A PERI-POSITION AND IN 2-POSITION BY AMINO, PREPARATION METHOD, AND APPLICATION THEREOF | TECHNICAL INST OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (CN) | 2022-11-02 | — | — | EP | disclosed |
| US-11439707-B2 | Hypocrellin derivative substituted both in a peri-position and in 2-position by amino, preparation method, and application thereof | Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (CN) | 2022-09-13 | — | — | US | disclosed |
| US-20210145968-A1 | HYPOCRELLIN DERIVATIVE SUBSTITUTED BOTH IN A PERI-POSITION AND IN 2-POSITION BY AMINO, PREPARATION METHOD, AND APPLICATION THEREOF | Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (CN) | 2021-05-20 | — | — | US | disclosed |
| EP-3680230-A1 | DERIVATIVES OF HYPOCRELLIN WITH PERI-POSITION AND 2-POSITION SIMULTANEOUSLY SUBSTITUTED BY AMINO GROUPS | Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (CN) | 2020-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210145968-A1 | HYPOCRELLIN DERIVATIVE SUBSTITUTED BOTH IN A PERI-POSITION AND IN 2-POSITION BY AMINO, PREPARATION METHOD, AND APPLICATION THEREOF | HCCS, PPOX, AAAS | L3MBTL1 1521/4885TP53 2452/4885KDM4E 973/4885 |
| US-11439707-B2 | Hypocrellin derivative substituted both in a peri-position and in 2-position by amino, preparation method, and application thereof | PPOX, AAAS, HCCS | L3MBTL1 2049/4885TP53 1837/4885KDM4E 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.