Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6370550 | 0.78 | HCRTR1 (0.43) | GAARAB9AMAPTKDM4EL3MBTL1 | |
| SCHEMBL13141290 | 0.72 | HCRTR1 (0.42) | GAARAB9AMAPTKDM4EL3MBTL1 | |
| SCHEMBL21784191 | 0.72 | PIK3CG (0.32) | — | |
| SCHEMBL6370538 | 0.72 | NPC1 (0.41) | RAB9AKDM4EL3MBTL1NPC1MAPK1 | |
| SCHEMBL13179274 | 0.71 | HCRTR1 (0.39) | GAARAB9AMAPTKDM4EL3MBTL1 | |
| SCHEMBL12506048 | 0.71 | PLAT (0.45) | RAB9ANPC1HCRTR1HCRTR2CNR2 | |
| SCHEMBL19625279 | 0.70 | NPC1 (0.47) | RAB9AKDM4EL3MBTL1NPC1MAPK1 | |
| SCHEMBL21210885 | 0.70 | HCRTR1 (0.35) | HCRTR1HCRTR2CNR2CA1CA2 | |
| SCHEMBL11967082 | 0.68 | RAB9A (0.40) | GAARAB9AMAPTKDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL876781 | 0.68 | NR1H4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185865-B1 | TETRAHYDRONAPTHTYRIDINE DERIVATIVES AS MGLUR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE. | MERCK SHARP & DOHME (US) | 2020-07-15 | — | — | EP | disclosed |