Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068259 | 0.83 | AR (0.40) | ARKDM4EHPGDALDH1A1HTT | |
| SCHEMBL12180304 | 0.78 | RET (0.41) | HPGDALDH1A1KMT2AHTR2ASMN1; SMN2 | |
| SCHEMBL8256560 | 0.78 | RET (0.41) | HPGDALDH1A1KMT2AHTR2ASMN1; SMN2 | |
| SCHEMBL29467973 | 0.78 | L3MBTL1 (0.35) | KDM4EHPGDALDH1A1HTTKMT2A | |
| SCHEMBL12180490 | 0.75 | ALDH1A1 (0.50) | ARKDM4EHPGDALDH1A1HTT | |
| SCHEMBL17813855 | 0.75 | AR (0.41) | ARKDM4EHPGDALDH1A1HTT | |
| SCHEMBL22211842 | 0.75 | AR (0.39) | ARKDM4EHPGDALDH1A1HTT | |
| SCHEMBL20925174 | 0.72 | EGFR (0.35) | KDM4EHPGDALDH1A1HTTKMT2A | |
| SCHEMBL17808239 | 0.72 | AR (0.39) | ARKDM4EHPGDALDH1A1HTT | |
| SCHEMBL16068183 | 0.72 | AR (0.39) | ARKDM4EHPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975030-B1 | DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-07-15 | — | — | EP | disclosed |