Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037386 | 0.80 | SIRT6 (0.41) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL30482977 | 0.77 | SIRT6 (0.46) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL2793061 | 0.77 | SIRT6 (0.47) | SIRT6ADRA1AHCAR3HSP90AA1HSP90AB1 | |
| SCHEMBL30874243 | 0.77 | SIRT6 (0.52) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL2222631 | 0.77 | SIRT6 (0.52) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL30301027 | 0.74 | SIRT6 (0.46) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL5042470 | 0.72 | HCAR3 (0.46) | SIRT6ADORA3TSHRMC4RADRA1A | |
| SCHEMBL5132655 | 0.70 | RPS6KB1 (0.46) | SIRT6 | |
| SCHEMBL5133491 | 0.70 | HCAR3 (0.43) | SIRT6TSHRHCAR3 | |
| SCHEMBL5042293 | 0.68 | SIRT6 (0.40) | SIRT6ADORA3TSHRMC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011083315-A1 | COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | WO | disclosed |