Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970752 | 0.88 | — | — | |
| SCHEMBL20747247 | 0.81 | NAMPT (0.38) | AKT2NAMPTNOS2HRH2ROCK2 | |
| SCHEMBL17950152 | 0.81 | MEN1 (0.46) | AKT2NAMPTNOS2HRH2ROCK2 | |
| SCHEMBL24866428 | 0.79 | AKT2 (0.44) | AKT2NAMPTNOS2HRH2ALDH1A1 | |
| SCHEMBL19001245 | 0.78 | HRH4 (0.42) | AKT2NAMPTNOS2KDM1ACYP1A2 | |
| SCHEMBL21099036 | 0.77 | HRH4 (0.44) | AKT2NAMPTNOS2HRH2ROCK2 | |
| SCHEMBL21263656 | 0.76 | NOS2 (0.44) | AKT2NOS2ALDH1A1LMNAHAT1 | |
| SCHEMBL5067336 | 0.76 | AKT2 (0.56) | AKT2MAOA | |
| Hydrochloric Acid SCHEMBL11590343 | 0.76 | AKT2 (0.61) | AKT2NOS2LMNA | |
| Hydrochloric Acid SCHEMBL31274777 | 0.76 | AKT2 (0.61) | AKT2NOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087051-B1 | BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME | ONCOTARTIS INC (US) | 2020-07-15 | — | — | EP | disclosed |