Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Colforsin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B known ✓ | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C known ✓ | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D known ✓ | Q08499 | 3/20 | 0.49 |
| ▸ | ADCY1 | Q08828 | 12/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Colforsin SCHEMBL8611895 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL8234478 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL6040365 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL16342714 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL4917705 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL23750589 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL1517319 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL4928 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL21530309 | 0.79 | ADCY1 (1.00) | ADCY1MAPK1CYP3A4TSHRBLM | |
| Colforsin SCHEMBL7643241 | 0.78 | ADCY1 (0.98) | ADCY1MAPK1CYP3A4TSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150208623-A1 | TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF | SANOFI (FR) | 2015-07-30 | — | — | US | disclosed |
| US-8981179-B2 | Transgenic non-human animal and uses thereof | SANOFI (US) | 2015-03-17 | — | — | US | disclosed |
| CN-102892881-B | Transgenic non-human animal and uses thereof | SANOFI SA | 2015-01-07 | — | — | CN | disclosed |
| CN-102892881-A | Transgenic non-human animal and uses thereof | SANOFI AVENTIS | 2013-01-23 | — | — | CN | disclosed |
| EP-2516634-A1 | TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF | SANOFI (FR) | 2012-10-31 | — | — | EP | disclosed |
| US-20120255041-A1 | TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF | SANOFI (FR) | 2012-10-04 | — | — | US | disclosed |
| WO-2011084659-A1 | TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF | SANOFI-AVENTIS (FR) | 2011-07-14 | — | — | WO | disclosed |