Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634900 | 0.79 | CYP2B6 (0.47) | MAPTKDM4EALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL28637832 | 0.78 | MAPT (0.44) | MAPTKMT2ACYP2C19HIF1ASMN1; SMN2 | |
| SCHEMBL2201585 | 0.72 | POLB (0.48) | MAPTALDH1A1S1PR5S1PR1CYP2C19 | |
| SCHEMBL14396643 | 0.69 | CYP2B6 (0.45) | MAPTALDH1A1KMT2ACYP2C19HIF1A | |
| SCHEMBL17810248 | 0.69 | CYP2B6 (0.67) | KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18909946 | 0.68 | KEAP1 (0.36) | ALDH1A1S1PR5S1PR1NOTUM | |
| SCHEMBL5733825 | 0.68 | L3MBTL1 (0.49) | MAPTKDM4EALDH1A1NOTUMKMT2A | |
| SCHEMBL2219066 | 0.67 | POLB (0.40) | MAPTALDH1A1S1PR5S1PR1NOTUM | |
| SCHEMBL17027050 | 0.67 | NOTUM (0.72) | ALDH1A1S1PR5S1PR1NOTUMKMT2A | |
| SCHEMBL15164290 | 0.66 | POLB (0.39) | MAPTS1PR5S1PR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |