Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | KDM1A | O60341 | 1/20 | 0.66 |
| ▸ | CXCL12 | P48061 | 9/20 | 0.65 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.65 |
| ▸ | TUBB | P07437 | 1/20 | 0.65 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.65 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.65 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.65 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.65 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.65 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.65 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.65 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.65 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.65 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.65 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.65 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.65 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.65 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221923 | 1.00 | RELA (0.68) | RELAKDM1ACXCL12TUBB4ATUBB | |
| SCHEMBL29803052 | 0.90 | NR1H4 (0.74) | RELANR1H4CA1CA2PTGS2 | |
| SCHEMBL16257539 | 0.90 | NR1H4 (0.74) | RELANR1H4CA1CA2PTGS2 | |
| SCHEMBL16257540 | 0.87 | ABCB1 (0.65) | NR1H4CA1CA2PTPN1PTGS1 | |
| SCHEMBL25205526 | 0.87 | CA1 (0.82) | CXCL12TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5474413 | 0.86 | ABCG2 (0.75) | RELACXCL12TUBB4ATUBBTUBA3C | |
| SCHEMBL13068505 | 0.86 | CXCL12 (0.74) | RELACXCL12TUBB4ATUBBTUBA3C | |
| SCHEMBL5474417 | 0.86 | ABCG2 (0.75) | RELACXCL12TUBB4ATUBBTUBA3C | |
| SCHEMBL5598912 | 0.85 | CXCL12 (0.82) | CXCL12TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2032114 | 0.85 | CXCL12 (0.82) | CXCL12TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889874-B2 | Imidazolone-chalcone derivatives as potential anticancer agent and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-11-18 | — | — | US | disclosed |
| US-8889874-B2 | Imidazolone-chalcone derivatives as potential anticancer agent and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-11-18 | — | — | US | disclosed |
| EP-2523941-B1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-10-15 | — | — | EP | disclosed |
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-14 | — | — | US | disclosed |
| EP-2523941-A2 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086412-A2 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066081-A1 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF | SIK1, SIK2, SIK3 | RELA 2491/4885KDM1A 2416/4885CXCL12 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.