Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223578 | 0.88 | FYN (0.48) | PDE4BHRH1IDO1TAAR1FYN | |
| SCHEMBL2220568 | 0.81 | PDE4B (0.42) | PDE4BHRH1IDO1MAOBTAAR1 | |
| SCHEMBL13273284 | 0.81 | PDE4B (0.50) | PDE4BHRH1IDO1TAAR1LMNA | |
| SCHEMBL2269848 | 0.78 | PDE4B (0.45) | PDE4BIDO1TAAR1LMNAPOLB | |
| SCHEMBL2220953 | 0.78 | NR1I3 (0.43) | PDE4BHRH1IDO1TAAR1LMNA | |
| SCHEMBL2616114 | 0.75 | IDO1 (0.47) | IDO1LMNAPOLBMAPT | |
| SCHEMBL2131570 | 0.75 | DHFR (0.51) | HRH1IDO1MAOBADORA1 | |
| SCHEMBL9250325 | 0.75 | MAOB (0.46) | HRH1IDO1MAOBTAAR1HIF1A | |
| SCHEMBL13275140 | 0.75 | NPC1 (0.55) | POLBGAAMAPT | |
| SCHEMBL2557747 | 0.75 | IDO1 (0.44) | HRH1IDO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |