Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055380 | 0.98 | L3MBTL1 (0.68) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| SCHEMBL2720932 | 0.95 | L3MBTL1 (0.58) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| Hydrochloric Acid SCHEMBL6818484 | 0.94 | L3MBTL1 (0.56) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| SCHEMBL5788139 | 0.84 | L3MBTL1 (0.52) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| SCHEMBL2223756 | 0.82 | L3MBTL1 (0.70) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| SCHEMBL30799059 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3PARP1CDC7PLK4 | |
| SCHEMBL22815820 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3PARP1CDC7PLK4 | |
| SCHEMBL8799328 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3KMT2APARP1CDC7 | |
| SCHEMBL13534478 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3MAPK1KMT2APARP1 | |
| SCHEMBL27383396 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3MAPK1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |