Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27165584 | 0.98 | L3MBTL1 (0.68) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL31512198 | 0.98 | L3MBTL1 (0.68) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL15516474 | 0.95 | L3MBTL1 (0.58) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL27383398 | 0.82 | L3MBTL1 (0.70) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL22815820 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL27383396 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL13534478 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL2222171 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL8799328 | 0.82 | L3MBTL1 (0.65) | L3MBTL1HRH3CDC7PLK4AURKA | |
| SCHEMBL7935783 | 0.81 | SIGMAR1 (0.46) | L3MBTL1HTR2CACHESMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |