Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078502 | 0.87 | PDE4B (0.43) | HDAC8HDAC1HDAC6PDE4BNPC1 | |
| SCHEMBL21721696 | 0.81 | NPC1 (0.47) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2229660 | 0.75 | NPC1 (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2227101 | 0.75 | HDAC8 (0.41) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2226098 | 0.74 | NPC1 (0.45) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL4027129 | 0.73 | TPH1 (0.51) | HDAC8HDAC1HDAC6HPGDTPH1 | |
| SCHEMBL3096751 | 0.73 | LMNA (0.59) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2560216 | 0.73 | HDAC1 (0.69) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222487 | 0.72 | HDAC1 (0.68) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222261 | 0.72 | NPC1 (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |