Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.38 |
| ▸ | LPL | P06858 | 6/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274938 | 0.85 | LIPG (0.38) | LIPGLPLDGAT1IRAK4AAK1 | |
| SCHEMBL2269953 | 0.81 | LIPG (0.39) | LIPGLPLDGAT1IRAK4EGFR | |
| SCHEMBL13275186 | 0.81 | LIPG (0.43) | LIPGLPLDGAT1IRAK4EGFR | |
| SCHEMBL255643 | 0.79 | CLK4 (0.44) | LIPGLPLDGAT1IRAK4ALPL | |
| SCHEMBL255715 | 0.77 | LIPG (0.44) | LIPGLPLDGAT1IRAK4KDR | |
| SCHEMBL13275056 | 0.76 | LIPG (0.49) | LIPGLPLDGAT1IRAK4EGFR | |
| SCHEMBL2222243 | 0.75 | DGAT1 (0.41) | LIPGLPLDGAT1PDGFRBKDR | |
| SCHEMBL2222388 | 0.75 | LIPG (0.38) | LIPGLPLDGAT1IRAK4ALPL | |
| SCHEMBL13274705 | 0.74 | LIPG (0.44) | LIPGLPLDGAT1IRAK4EGFR | |
| SCHEMBL12516572 | 0.74 | DGAT1 (0.57) | LIPGLPLDGAT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |