Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15597241 | 1.00 | EPHX2 (0.61) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL15532610 | 0.99 | EPHX2 (0.59) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL17471623 | 0.91 | EPHX2 (0.61) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL24201247 | 0.87 | EPHX2 (0.62) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL24201340 | 0.87 | EPHX2 (0.62) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL19509238 | 0.86 | EPHX2 (0.81) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL17457691 | 0.85 | ALDH1A1 (0.61) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL24201255 | 0.84 | EPHX2 (0.60) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL19509240 | 0.83 | EPHX2 (0.62) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL30927843 | 0.83 | ALDH1A1 (0.66) | EPHX2ALDH1A1SMN1; SMN2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124483-B2 | HER3 ligands and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200223799-A1 | HER3 LIGANDS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124483-B2 | HER3 ligands and uses thereof | ERBB3, ERBB2, EGFR | EPHX2 850/4885ALDH1A1 3637/4885SMN1; SMN2 4500/4885 |
| US-20200223799-A1 | HER3 LIGANDS AND USES THEREOF | ERBB3, ERBB2, EGFR | EPHX2 850/4885ALDH1A1 3637/4885SMN1; SMN2 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.