Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | PIR | O00625 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227204 | 0.97 | MAPT (0.56) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL29566033 | 0.90 | MAPT (0.55) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL4290086 | 0.90 | MAPT (0.55) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL29363081 | 0.88 | MAPT (0.53) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL30874422 | 0.82 | NPC1 (0.44) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL22227191 | 0.82 | NPC1 (0.44) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL22225987 | 0.81 | NPC1 (0.44) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL22225997 | 0.80 | HPGD (0.64) | ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL3732847 | 0.80 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL20580612 | 0.78 | MAPT (0.56) | MAPTKDM4EALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |