Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226400 | 0.93 | NNMT (0.64) | NNMTHPGDALDH1A1CRBNKDM4E | |
| SCHEMBL22226404 | 0.92 | NNMT (0.59) | NNMTHPGDALDH1A1CRBNKDM4E | |
| SCHEMBL24463699 | 0.84 | NNMT (0.56) | NNMTHPGDPIK3C3CRBNGRM5 | |
| SCHEMBL22226405 | 0.83 | NNMT (0.46) | NNMTHPGDALDH1A1KDM4EPOLB | |
| SCHEMBL8389254 | 0.83 | PIK3C3 (0.52) | NNMTHPGDALDH1A1PIK3C3CYP11B2 | |
| SCHEMBL21201821 | 0.80 | HPGD (0.52) | NNMTHPGDALDH1A1KDM4EPOLB | |
| SCHEMBL22226402 | 0.80 | NNMT (0.57) | NNMTHPGDCRBNVNN1CYP11B2 | |
| SCHEMBL22225998 | 0.79 | HPGD (0.51) | NNMTHPGDALDH1A1KDM4EPOLB | |
| SCHEMBL24099729 | 0.78 | NNMT (0.55) | NNMTHPGDPIK3C3CRBNVNN1 | |
| SCHEMBL22226401 | 0.77 | HPGD (0.43) | HPGDALDH1A1KDM4EPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |