Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227198 | 0.91 | USP30 (0.37) | SRD5A1USP30SIRT2SIRT1GPR119 | |
| SCHEMBL22227273 | 0.87 | HPGD (0.35) | SRD5A1USP30GPR119HDAC4 | |
| SCHEMBL22226002 | 0.86 | SRD5A1 (0.36) | SRD5A1USP30SIRT2SIRT1GRM5 | |
| SCHEMBL22226788 | 0.79 | USP30 (0.42) | SRD5A1USP30SIRT2SIRT1GPR119 | |
| SCHEMBL24100124 | 0.79 | USP30 (0.49) | SRD5A1USP30SIRT2SIRT1SCN9A | |
| SCHEMBL22226787 | 0.79 | SRD5A1 (0.38) | SRD5A1USP30SIRT2SIRT1CA12 | |
| SCHEMBL22227157 | 0.78 | MEN1 (0.36) | SRD5A1SIRT2SIRT1GPR119HDAC4 | |
| SCHEMBL19859484 | 0.77 | DGAT1 (0.48) | DGAT1 | |
| SCHEMBL22207532 | 0.76 | USP30 (0.35) | SRD5A1USP30SIRT2SIRT1GPR119 | |
| SCHEMBL22227019 | 0.74 | GNE (0.43) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |