Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201865 | 0.96 | NNMT (0.47) | NNMTGRM5NPC1RAB9AALDH1A1 | |
| SCHEMBL12169366 | 0.90 | GRM5 (0.52) | NNMTGRM5ALDH1A1MAPK1P4HA1 | |
| SCHEMBL31133539 | 0.90 | GRM5 (0.52) | NNMTGRM5ALDH1A1MAPK1P4HA1 | |
| SCHEMBL22225988 | 0.84 | NNMT (0.42) | NNMTGRM5NPC1RAB9AALDH1A1 | |
| SCHEMBL22225953 | 0.80 | NNMT (0.43) | NNMTGRM5NPC1RAB9AALDH1A1 | |
| SCHEMBL21782980 | 0.78 | NNMT (0.68) | NNMTGRM5NPC1RAB9AALDH1A1 | |
| SCHEMBL22225998 | 0.78 | HPGD (0.51) | NNMTALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL25787851 | 0.77 | NNMT (0.62) | NNMTGRM5ALOX5APFEN1PIK3CA | |
| SCHEMBL14242971 | 0.77 | GRM5 (0.48) | NNMTGRM5ALOX5APFEN1KDM4E | |
| SCHEMBL5306512 | 0.76 | NNMT (0.75) | NNMTGRM5ALDH1A1P4HA1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |