Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 5/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21782980 | 0.95 | NNMT (0.68) | NNMTKDM4EMAPTALDH1A1CRBN | |
| SCHEMBL1680658 | 0.90 | NNMT (0.73) | NNMTKDM4EMAPTALDH1A1CRBN | |
| SCHEMBL25787747 | 0.86 | NNMT (1.00) | NNMTKDM4EMAPTCRBNGRM5 | |
| SCHEMBL30968499 | 0.82 | NNMT (0.68) | NNMTKDM4EMAPTALDH1A1PIK3C3 | |
| SCHEMBL20722588 | 0.82 | NNMT (0.68) | NNMTKDM4EMAPTALDH1A1PIK3C3 | |
| SCHEMBL22225983 | 0.80 | NNMT (0.50) | NNMTKDM4EMAPTALDH1A1CRBN | |
| SCHEMBL22226400 | 0.80 | NNMT (0.64) | NNMTKDM4EALDH1A1CRBNGRM5 | |
| SCHEMBL22226923 | 0.79 | NNMT (0.63) | NNMTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL21772832 | 0.78 | NNMT (0.62) | NNMTKDM4EMAPTALDH1A1CRBN | |
| SCHEMBL21201865 | 0.77 | NNMT (0.47) | NNMTKDM4EMAPTALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |
| EP-1833831-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069258-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-06-29 | — | — | WO | disclosed |