Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226788 | 0.91 | USP30 (0.42) | USP30PIK3CDGPR119PIK3CAMAPK1 | |
| SCHEMBL22227265 | 0.87 | USP30 (0.41) | USP30PIK3CDPIK3CAALDH1A1CYP2C9 | |
| SCHEMBL22226001 | 0.86 | USP30 (0.42) | USP30PIK3CDPIK3CASCN9ANPC1 | |
| SCHEMBL22226918 | 0.84 | USP30 (0.48) | USP30PIK3CDALDH1A1SCN9ANPC1 | |
| SCHEMBL22227202 | 0.81 | USP30 (0.42) | USP30PIK3CDPIK3CAMAPK1ALDH1A1 | |
| SCHEMBL22227198 | 0.80 | USP30 (0.37) | USP30PIK3CDGPR119PIK3CAMAPK1 | |
| SCHEMBL24100124 | 0.79 | USP30 (0.49) | USP30PIK3CDPIK3CAMAPK1ALDH1A1 | |
| SCHEMBL22226783 | 0.76 | GRM5 (0.44) | USP30PIK3CDPIK3CANPC1RAB9A | |
| SCHEMBL24100933 | 0.76 | GRM5 (0.42) | USP30PIK3CDPIK3CACRBN | |
| SCHEMBL22226875 | 0.75 | HPGD (0.51) | USP30ALDH1A1KMT2ACYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |