Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222893 | 0.89 | KDM4E (0.52) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL2225912 | 0.80 | CD274 (0.47) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL2223195 | 0.80 | KDM4E (0.47) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL2225112 | 0.79 | KDM4E (0.49) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL14554261 | 0.79 | NPC1 (0.50) | KDM4ELMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15678972 | 0.76 | MAPT (0.42) | KDM4ELMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL14554258 | 0.76 | KDM4E (0.44) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL2223087 | 0.76 | MEN1 (0.47) | KDM4ELMNAALDH1A1HTTTSHR | |
| SCHEMBL2222903 | 0.75 | HTR3E (0.47) | KDM4ELMNAALDH1A1HTTHPGD | |
| Hydrochloric Acid SCHEMBL2225347 | 0.75 | MEN1 (0.47) | KDM4ELMNAALDH1A1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |