Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222669 | 0.87 | MEN1 (0.47) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| SCHEMBL2222854 | 0.77 | HTR3E (0.47) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| SCHEMBL2222743 | 0.75 | KDM4E (0.58) | FAAHALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL13822280 | 0.75 | DRD2 (0.51) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL7235226 | 0.74 | HTR3E (0.61) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| Hydrochloric Acid SCHEMBL2222910 | 0.74 | HTR3E (0.44) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| Hydrochloric Acid SCHEMBL2225698 | 0.73 | FAAH (0.51) | FAAHMGLLALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2221587 | 0.73 | HTR3E (0.42) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| SCHEMBL2224886 | 0.73 | MEN1 (0.50) | HTR3EHTR3BHTR1AHTR2CHTR3A | |
| Hydrochloric Acid SCHEMBL14485309 | 0.72 | HTR3E (0.43) | HTR3EHTR3BHTR1AHTR2CHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |