SCHEMBL2222969

SCHEMBL2222969

CN(c1ncccc1C(=O)O)[C@@H]1CCN(Cc2ccccc2OC(F)(F)F)C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.46
DRD4 P21917 3/20 0.46
DRD3 P35462 3/20 0.46
GMNN O75496 2/20 0.46
ALDH1A1 P00352 2/20 0.46
LMNA P02545 2/20 0.46
HPGD P15428 2/20 0.46
PMP22 Q01453 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
TP53 P04637 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
EPHX2 P34913 5/20 0.43
CYP2C9 P11712 3/20 0.43
CYP2J2 P51589 3/20 0.43
RBP4 P02753 1/20 0.43
TTR P02766 1/20 0.43
CHRM4 P08173 3/20 0.41
PDE2A O00408 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2222943 0.89 DRD2 (0.47) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2227127 0.89 DRD2 (0.47) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL12515892 0.77 DRD2 (0.53) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223925 0.77 DRD2 (0.53) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223998 0.75 DRD4 (0.48) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223298 0.74 DRD2 (0.46) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2224761 0.74 ALDH1A1 (0.47) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2226949 0.74 DRD2 (0.47) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2221709 0.74 ALDH1A1 (0.47) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2224077 0.73 DRD2 (0.44) DRD2DRD4DRD3GMNNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2729149-A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS Glaxo Group Limited (GB) 2014-05-14 EP disclosed
WO-2013006596-A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS GLAXO GROUP LIMITED (GB) 2013-01-10 WO disclosed
EP-2523665-A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS Glaxo Group Limited (GB) 2012-11-21 EP disclosed
WO-2011088201-A1 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS GLAXO GROUP LIMITED (GB) 2011-07-21 WO disclosed