Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223041 | 1.00 | USP30 (0.47) | USP30POLBGPR119JAK2JAK1 | |
| SCHEMBL13822281 | 0.91 | USP30 (0.47) | USP30POLBGPR119JAK2JAK1 | |
| SCHEMBL13822282 | 0.91 | USP30 (0.47) | USP30POLBGPR119JAK2JAK1 | |
| SCHEMBL21783090 | 0.79 | USP30 (0.58) | USP30GPR119JAK2JAK1VNN1 | |
| SCHEMBL22087745 | 0.79 | USP30 (0.58) | USP30GPR119JAK2JAK1VNN1 | |
| SCHEMBL8406581 | 0.76 | GPR119 (0.52) | USP30POLBGPR119 | |
| SCHEMBL8409489 | 0.76 | GPR119 (0.47) | USP30POLBGPR119 | |
| SCHEMBL8409617 | 0.75 | GPR119 (0.50) | USP30POLBGPR119 | |
| SCHEMBL28834262 | 0.74 | USP30 (0.48) | USP30POLBGPR119JAK2JAK1 | |
| SCHEMBL28834263 | 0.74 | USP30 (0.48) | USP30POLBGPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |