Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408098 | 0.90 | GPR119 (0.47) | GPR119POLBNPC1ALDH1A1MAPT | |
| SCHEMBL8409078 | 0.84 | GPR119 (0.46) | GPR119POLBKDM4EPKM | |
| SCHEMBL8409683 | 0.84 | KDM4E (0.48) | GPR119POLBKDM4EPKM | |
| SCHEMBL8409517 | 0.83 | GPR119 (0.45) | GPR119POLBUSP30KDM4EPKM | |
| SCHEMBL8793652 | 0.83 | GPR119 (0.45) | GPR119POLB | |
| SCHEMBL8406581 | 0.82 | GPR119 (0.52) | GPR119POLBUSP30 | |
| SCHEMBL9093945 | 0.82 | DRD2 (0.40) | GPR119ALDH1A1 | |
| SCHEMBL3336117 | 0.80 | GPR119 (0.54) | GPR119POLB | |
| SCHEMBL8409617 | 0.79 | GPR119 (0.50) | GPR119POLBALDH1A1MAPTUSP30 | |
| SCHEMBL8793643 | 0.77 | POLB (0.54) | GPR119POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866589-A | Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds | PHARMACIA & UPJOHN COMPANY (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1996018628-A1 | ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-06-20 | — | — | WO | disclosed |