⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016006 | 1.00 | GRM5 (0.53) | — | |
| SCHEMBL29413268 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL31421455 | 0.98 | GRM5 (0.51) | — | |
| Phenol SCHEMBL27652947 | 0.86 | GRM5 (0.47) | — | |
| SCHEMBL21121939 | 0.86 | GRM5 (0.50) | — | |
| SCHEMBL10361196 | 0.84 | TRPA1 (0.44) | — | |
| SCHEMBL5562895 | 0.79 | CLK4 (0.59) | — | |
| SCHEMBL16398425 | 0.79 | GRM5 (0.47) | — | |
| SCHEMBL2743433 | 0.78 | MAPKAPK2 (0.48) | — | |
| SCHEMBL12804928 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1649 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805172-B | Method for synthesizing asymmetric heterocyclic diaryl methane compound | 陇东学院 | 2024-04-23 | — | — | CN | claimed |
| CN-115572747-B | Topiroxostat preparation method | 湖南一格制药有限公司 | 2023-05-05 | — | — | CN | claimed |
| CN-115572747-A | Preparation method of topiroxostat | 湖南一格制药有限公司 | 2023-01-06 | — | — | CN | claimed |
| US-20210323944-A1 | IVOSIDENIB FORMS AND PHARMACEUTICAL COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2021-10-21 | — | — | US | claimed |
| EP-3817744-A1 | IVOSIDENIB FORMS AND PHARMACEUTICAL COMPOSITIONS | Agios Pharmaceuticals, Inc. (US) | 2021-05-12 | — | — | EP | claimed |
| CN-112367995-A | Evonib forms and pharmaceutical compositions | 安吉奥斯医药品有限公司 | 2021-02-12 | — | — | CN | claimed |
| CN-106083707-B | A kind of synthetic method of asymmetric heteroaryl thioether | 温州大学 | 2018-10-26 | — | — | CN | claimed |
| CN-107602458-A | A kind of preparation method of cyclenes alkenyl position Acetoxylation | 重庆大学 | 2018-01-19 | — | — | CN | claimed |
| CN-104945383-B | Hold in the palm his preparation method of pyrrole department | 山东金城医药化工股份有限公司 | 2017-12-08 | — | — | CN | claimed |
| CN-104945383-A | Preparation method for topiroxostat | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2015-09-30 | — | — | CN | claimed |
| JP-4243867-A | — | — | None | — | — | JP | disclosed |
| CN-122080069-A | Phospholipid compounds and uses thereof | — | 2026-05-26 | — | — | CN | disclosed |
| EP-4735423-A1 | KV7 MODULATORS | Saniona A/S (DK) | 2026-05-06 | — | — | EP | disclosed |
| EP-4731207-A2 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS | Merck Sharp & Dohme LLC (US) | 2026-04-29 | — | — | EP | disclosed |
| US-20260109692-A1 | KCNT1 INHIBITORS AND METHODS OF USE | UCB Biopharma SRL (BE) | 2026-04-23 | — | — | US | disclosed |
| US-4152437-A | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use | MERCK & CO., INC. (US) | 1979-05-01 | — | — | US | disclosed |
| US-4145425-A | Substituted (3-loweralkylamino-2-R1 0-propoxy)pyridines, their preparation and use | MERCK & CO., INC. (US) | 1979-03-20 | — | — | US | disclosed |
| US-4092419-A | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use | MERCK & CO., INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4031106-A | Synthesis of aromatic amines by reaction of aromatic compounds with ammonia | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-06-21 | — | — | US | disclosed |
| US-4001260-A | NICKEL-NICKEL OXIDE-ZIRCONIUM OXIDE AMINATION CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |