Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LGMN | Q99538 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222441 | 0.78 | HDAC4 (0.37) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2223402 | 0.76 | LMNA (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2224739 | 0.73 | HDAC8 (0.39) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2266329 | 0.72 | GAA (0.40) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222405 | 0.71 | HDAC1 (0.42) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2224731 | 0.70 | HDAC8 (0.38) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222261 | 0.69 | NPC1 (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2221808 | 0.69 | HDAC8 (0.37) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2223339 | 0.67 | HDAC8 (0.43) | HDAC8HDAC1HDAC6LMNAPDE4B | |
| SCHEMBL2222335 | 0.67 | HDAC8 (0.44) | HDAC8HDAC1HDAC6LMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |