Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140848 | 0.99 | NPC1 (0.43) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL282809 | 0.99 | NPC1 (0.43) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL2222051 | 0.97 | NPC1 (0.42) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL2219935 | 0.97 | NPC1 (0.42) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL2223454 | 0.97 | NPC1 (0.42) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL2223173 | 0.97 | NPC1 (0.42) | NPC1RAB9AKDM4EESR1PGR | |
| SCHEMBL14635456 | 0.88 | ALOX15 (0.41) | KDM4EHRH3ALOX15STSPTPN5 | |
| SCHEMBL14331053 | 0.79 | ALOX15 (0.45) | KDM4EHRH3ALOX15STSMEN1 | |
| SCHEMBL2561686 | 0.77 | ALDH1A1 (0.46) | NPC1RAB9AKDM4EPOLBALOX15 | |
| SCHEMBL30140835 | 0.77 | ALDH1A1 (0.46) | NPC1RAB9AKDM4EPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521720-B1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI SA (FR) | 2014-03-12 | — | — | EP | disclosed |
| US-8658809-B2 | Process for the preparation of dronedarone | SANOFI (FR) | 2014-02-25 | — | — | US | disclosed |
| US-20120330036-A1 | Process for the preparation of dronedarone | SANOFI (FR) | 2012-12-27 | — | — | US | disclosed |
| EP-2521720-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011083346-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120330036-A1 | Process for the preparation of dronedarone | CYP2D6, CYP3A4, CYP2B6 | NPC1 714/4885RAB9A 257/4885KDM4E 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.