Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236103 | 0.87 | DDR1 (0.44) | FLT3RAB9ANPC1HIF1ASMN1; SMN2 | |
| SCHEMBL22236104 | 0.86 | RXFP1 (0.47) | FLT3RAB9ANPC1HIF1ASMN1; SMN2 | |
| SCHEMBL22236222 | 0.85 | RXFP1 (0.49) | RAB9ANPC1USP2HIF1ASMN1; SMN2 | |
| SCHEMBL22235634 | 0.84 | RXFP1 (0.46) | — | |
| SCHEMBL3821817 | 0.82 | AURKA (0.60) | RAB9ANPC1HIF1ASMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2267738 | 0.80 | AURKA (0.55) | RAB9ANPC1USP2HIF1ASMN1; SMN2 | |
| SCHEMBL22235999 | 0.79 | CDK5 (0.62) | RAB9AALDH1A1MAPT | |
| SCHEMBL22236099 | 0.79 | NAMPT (0.53) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL12962933 | 0.78 | RAB9A (0.72) | FLT3RAB9ANPC1NLRP3HIF1A | |
| SCHEMBL3822413 | 0.77 | AURKA (0.54) | RAB9ANPC1HIF1ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |