Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | FLT1 | P17948 | 5/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236104 | 0.89 | RXFP1 (0.47) | RXFP1HIF1AMAPTNPC1RAB9A | |
| SCHEMBL22236040 | 0.86 | FLT1 (0.42) | RXFP1MAPTKDRFLT1ABL1 | |
| SCHEMBL22235681 | 0.85 | FLT3 (0.55) | HIF1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL22235634 | 0.84 | RXFP1 (0.46) | RXFP1KDRFLT1ABL1EGFR | |
| SCHEMBL22235999 | 0.82 | CDK5 (0.62) | RXFP1MAPTRAB9AALDH1A1 | |
| SCHEMBL22236099 | 0.81 | NAMPT (0.53) | MEN1KMT2AMAPTLMNANPC1 | |
| SCHEMBL22258286 | 0.77 | MAPT (0.49) | MEN1KMT2AMAPTLMNAL3MBTL1 | |
| SCHEMBL22236103 | 0.77 | DDR1 (0.44) | HIF1AMAPTL3MBTL1NPC1MAPK1 | |
| SCHEMBL22235674 | 0.75 | KDR (0.51) | HIF1AMAPTLMNAL3MBTL1MAPK1 | |
| SCHEMBL22258475 | 0.74 | NPC1 (0.49) | RXFP1MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |