Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.47 |
| ▸ | CLK2 | P49760 | 7/20 | 0.47 |
| ▸ | CLK3 | P49761 | 7/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | PAICS | P22234 | 2/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235785 | 0.91 | DYRK1A (0.47) | DYRK1ACLK2CLK3PAICSMAPK7 | |
| SCHEMBL22236190 | 0.89 | DYRK1A (0.52) | DYRK1ACLK2CLK3PAICSGSK3B | |
| SCHEMBL22235838 | 0.89 | DYRK1A (0.59) | DYRK1ACLK2CLK3MAPK7GSK3B | |
| SCHEMBL22236002 | 0.88 | CLK2 (0.45) | DYRK1ACLK2CLK3TDO2 | |
| SCHEMBL22236034 | 0.86 | DYRK1A (0.54) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL13993605 | 0.84 | CDK14 (0.47) | DYRK1ACLK2CLK3PAICSMAPK7 | |
| SCHEMBL22236107 | 0.82 | CLK2 (0.57) | DYRK1ACLK2CLK3SLC6A3KCNH2 | |
| SCHEMBL22236189 | 0.82 | DYRK1A (0.59) | DYRK1ACLK2CLK3MAPK7GSK3B | |
| SCHEMBL22236128 | 0.80 | DYRK1A (0.54) | DYRK1ACLK2CLK3SLC6A3KCNH2 | |
| SCHEMBL22235987 | 0.79 | DYRK1A (0.59) | DYRK1ACLK2CLK3KCNH2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |