Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 5/20 | 0.45 |
| ▸ | CLK3 | P49761 | 5/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | USP36 | Q9P275 | 9/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235785 | 0.90 | DYRK1A (0.47) | CLK2CLK3DYRK1ATDO2 | |
| SCHEMBL22236259 | 0.90 | DYRK1A (0.57) | CLK2CLK3DYRK1AUSP36TDO2 | |
| SCHEMBL22236176 | 0.88 | DYRK1A (0.47) | CLK2CLK3DYRK1ATDO2 | |
| SCHEMBL22236190 | 0.86 | DYRK1A (0.52) | CLK2CLK3DYRK1A | |
| SCHEMBL22236128 | 0.85 | DYRK1A (0.54) | CLK2CLK3DYRK1A | |
| SCHEMBL22236034 | 0.83 | DYRK1A (0.54) | CLK2CLK3DYRK1A | |
| SCHEMBL22236223 | 0.83 | USP36 (0.50) | CLK2DYRK1AUSP36 | |
| SCHEMBL22258278 | 0.82 | CLK2 (0.55) | CLK2CLK3DYRK1AUSP36 | |
| SCHEMBL22236189 | 0.81 | DYRK1A (0.59) | CLK2CLK3DYRK1ATDO2 | |
| SCHEMBL22236050 | 0.79 | CLK2 (0.57) | CLK2CLK3DYRK1AUSP36 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |