Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.54 |
| ▸ | CLK2 | P49760 | 7/20 | 0.54 |
| ▸ | CLK3 | P49761 | 6/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236034 | 0.86 | DYRK1A (0.54) | DYRK1ACLK2CLK3GSK3BWNT1 | |
| SCHEMBL22236002 | 0.85 | CLK2 (0.45) | DYRK1ACLK2CLK3 | |
| SCHEMBL22236026 | 0.84 | DYRK1A (0.75) | DYRK1ACLK2CLK3GSK3BWNT1 | |
| SCHEMBL22236111 | 0.84 | DYRK1A (0.55) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235792 | 0.84 | ABL1 (0.45) | DYRK1ACLK2WNT1 | |
| SCHEMBL22235823 | 0.83 | DYRK1A (0.76) | DYRK1ACLK2CLK3GSK3BWNT1 | |
| SCHEMBL22236190 | 0.83 | DYRK1A (0.52) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236058 | 0.83 | USP36 (0.44) | DYRK1ACLK2WNT1SLC6A3KCNH2 | |
| SCHEMBL22236223 | 0.83 | USP36 (0.50) | DYRK1ACLK2WNT1 | |
| SCHEMBL22236228 | 0.82 | CLK2 (0.41) | DYRK1ACLK2WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |