Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.58 |
| ▸ | CLK2 | P49760 | 5/20 | 0.58 |
| ▸ | CLK3 | P49761 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | USP36 | Q9P275 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236221 | 0.90 | DYRK1A (0.60) | DYRK1ACLK2CLK3ABL1DGAT1 | |
| SCHEMBL22235978 | 0.89 | DYRK1A (0.59) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22258271 | 0.89 | USP36 (0.53) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22235863 | 0.88 | CLK2 (0.51) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22258272 | 0.88 | USP36 (0.53) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22235626 | 0.88 | DYRK1A (0.75) | DYRK1ACLK2CLK3ABL1WNT1 | |
| SCHEMBL22258278 | 0.87 | CLK2 (0.55) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22235745 | 0.86 | SMN1; SMN2 (0.62) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22235747 | 0.85 | CLK2 (0.55) | DYRK1ACLK2CLK3SMN1; SMN2MAPT | |
| SCHEMBL22236223 | 0.81 | USP36 (0.50) | DYRK1ACLK2USP36SCN10AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |