Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP36 | Q9P275 | 14/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235792 | 0.91 | ABL1 (0.45) | USP36KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL22236228 | 0.91 | CLK2 (0.41) | USP36KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL22236058 | 0.90 | USP36 (0.44) | USP36KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL22236062 | 0.89 | PTPN1 (0.42) | USP36KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL22236263 | 0.87 | SLC6A3 (0.48) | KCNQ3KCNQ2KCNE1KCNQ1CLK2 | |
| SCHEMBL22236014 | 0.86 | CLK2 (0.52) | CLK2DYRK1A | |
| SCHEMBL22258279 | 0.85 | DGAT1 (0.47) | USP36 | |
| SCHEMBL22258271 | 0.85 | USP36 (0.53) | USP36KCNQ3KCNQ2SCN10ACLK2 | |
| SCHEMBL22258272 | 0.85 | USP36 (0.53) | USP36KCNQ3KCNQ2SCN10ACLK2 | |
| SCHEMBL22258278 | 0.84 | CLK2 (0.55) | USP36KCNQ3KCNQ2CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |