Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP36 | Q9P275 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 5/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | CLK3 | P49761 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22258272 | 0.99 | USP36 (0.53) | USP36MAPTSMN1; SMN2STAT3KCNQ3 | |
| SCHEMBL22258278 | 0.93 | CLK2 (0.55) | USP36MAPTSMN1; SMN2STAT3KCNQ3 | |
| SCHEMBL22235745 | 0.93 | SMN1; SMN2 (0.62) | USP36MAPTSMN1; SMN2STAT3CLK2 | |
| SCHEMBL22236201 | 0.89 | DYRK1A (0.58) | USP36MAPTSMN1; SMN2STAT3CLK2 | |
| SCHEMBL22236105 | 0.89 | KCNQ3 (0.55) | MAPTSMN1; SMN2STAT3KCNQ3KCNQ2 | |
| SCHEMBL22236037 | 0.87 | DYRK1A (0.53) | MAPTSMN1; SMN2KCNQ3KCNQ2CLK2 | |
| SCHEMBL22236270 | 0.86 | DYRK1A (0.53) | MAPTSMN1; SMN2KCNQ3KCNQ2CLK2 | |
| SCHEMBL22235966 | 0.86 | KCNQ3 (0.52) | MAPTSMN1; SMN2STAT3KCNQ3KCNQ2 | |
| SCHEMBL22236223 | 0.85 | USP36 (0.50) | USP36KCNQ3KCNQ2CLK2DYRK1A | |
| SCHEMBL22258273 | 0.85 | KCNQ3 (0.51) | MAPTSMN1; SMN2STAT3KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |