Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 6/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.57 |
| ▸ | CLK3 | P49761 | 4/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236105 | 0.93 | KCNQ3 (0.55) | CLK2DYRK1ACLK3KCNQ3KCNQ2 | |
| SCHEMBL22236249 | 0.90 | RAB9A (0.53) | CLK2DYRK1ACLK3KCNQ3KCNQ2 | |
| SCHEMBL22236107 | 0.90 | CLK2 (0.57) | CLK2DYRK1ACLK3HDAC2HDAC3 | |
| SCHEMBL22258278 | 0.89 | CLK2 (0.55) | CLK2DYRK1ACLK3HDAC2HDAC3 | |
| SCHEMBL22235736 | 0.88 | CLK2 (0.73) | CLK2DYRK1ACLK3HDAC2HDAC3 | |
| SCHEMBL22236221 | 0.86 | DYRK1A (0.60) | CLK2DYRK1ACLK3KCNQ3KCNQ2 | |
| SCHEMBL22258500 | 0.85 | CLK2 (0.44) | CLK2DYRK1ACLK3HDAC2HDAC3 | |
| SCHEMBL22236037 | 0.82 | DYRK1A (0.53) | CLK2DYRK1ACLK3KCNQ3KCNQ2 | |
| SCHEMBL22235785 | 0.82 | DYRK1A (0.47) | CLK2DYRK1ACLK3MAPK7CHRNB2 | |
| SCHEMBL22236270 | 0.81 | DYRK1A (0.53) | CLK2DYRK1ACLK3KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |