Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.52 |
| ▸ | WNT1 | P04628 | 4/20 | 0.52 |
| ▸ | CLK2 | P49760 | 7/20 | 0.51 |
| ▸ | CLK3 | P49761 | 6/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22236105 | 0.92 | KCNQ3 (0.55) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22236231 | 0.90 | CLK2 (0.57) | DYRK1ACLK2CLK3KCNQ3KCNQ2 | |
| SCHEMBL22235783 | 0.90 | RAB9A (0.60) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22235745 | 0.89 | SMN1; SMN2 (0.62) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22235928 | 0.89 | DYRK1A (0.62) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22236221 | 0.86 | DYRK1A (0.60) | DYRK1AWNT1CLK2CLK3KCNQ3 | |
| SCHEMBL22258528 | 0.85 | DYRK1A (0.44) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22236189 | 0.83 | DYRK1A (0.59) | DYRK1ACLK2CLK3CLK1GSK3B | |
| SCHEMBL22236037 | 0.81 | DYRK1A (0.53) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 | |
| SCHEMBL22236270 | 0.81 | DYRK1A (0.53) | RAB9AL3MBTL1SMN1; SMN2DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |