Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754448 | 1.00 | DRD2 (0.39) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL19714365 | 0.96 | ALDH1A1 (0.42) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL16754631 | 0.96 | GRM5 (0.42) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL17777053 | 0.96 | GRM5 (0.42) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL19714249 | 0.95 | MAPT (0.43) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL20720999 | 0.95 | GRM5 (0.40) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL17769702 | 0.95 | GRM5 (0.40) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL19670604 | 0.94 | NTRK1 (0.39) | DRD2DRD4DRD3GRM5NTRK1 | |
| SCHEMBL16754328 | 0.94 | NTRK1 (0.39) | DRD2DRD4DRD3GRM5NTRK1 | |
| SCHEMBL19714016 | 0.93 | NTRK1 (0.38) | DRD2DRD4DRD3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |