Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239708 | 0.90 | MEN1 (0.32) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22240073 | 0.90 | HTT (0.34) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22239993 | 0.89 | KDM4E (0.35) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22240325 | 0.89 | MEN1 (0.32) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22240214 | 0.89 | MEN1 (0.32) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22239757 | 0.87 | MEN1 (0.35) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22240057 | 0.87 | MEN1 (0.34) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL22240215 | 0.86 | NOS2 (0.32) | MEN1KMT2AHTTPOLBHPGD | |
| SCHEMBL22239936 | 0.85 | MEN1 (0.36) | MEN1KMT2AHTTMAPTNPC1 | |
| SCHEMBL22240059 | 0.85 | AXL (0.31) | MEN1KMT2AHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |