Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 1/20 | 0.31 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22240057 | 0.90 | MEN1 (0.34) | ALDH1A1LMNARAB9AMEN1KMT2A | |
| SCHEMBL22240073 | 0.89 | HTT (0.34) | KDM4EALDH1A1ALOX12MEN1KMT2A | |
| SCHEMBL22240267 | 0.89 | MEN1 (0.34) | RAB9AMEN1KMT2AHTTPOLB | |
| SCHEMBL22239708 | 0.89 | MEN1 (0.32) | KDM4EALDH1A1ALOX12MEN1KMT2A | |
| SCHEMBL22240325 | 0.88 | MEN1 (0.32) | HRH4MEN1KMT2AHTTPOLB | |
| SCHEMBL22240214 | 0.88 | MEN1 (0.32) | HRH4MEN1KMT2AHTTPOLB | |
| SCHEMBL22240059 | 0.87 | AXL (0.31) | KDM4EALDH1A1ALOX12LMNARAB9A | |
| SCHEMBL22240215 | 0.87 | NOS2 (0.32) | KDM4EMEN1KMT2AHTTPOLB | |
| SCHEMBL22239757 | 0.86 | MEN1 (0.35) | ALDH1A1RAB9AMEN1KMT2AHTT | |
| SCHEMBL22240292 | 0.86 | MEN1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |