SCHEMBL22244129

SCHEMBL22244129

CCc1cccc(N(c2ccc(C)cc2)c2ccc(-c3ccc(-c4ccc(N(c5ccc(C)cc5)c5cccc(CC)c5)cc4)cc3)cc2)c1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.41
CYP2C19 P33261 1/20 0.41
SIGMAR1 Q99720 12/20 0.40
RAPGEF4 Q8WZA2 1/20 0.38
PTGS2 P35354 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
RAB9A P51151 1/20 0.37
NISCH Q9Y2I1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21392008 0.95 CYP2C19 (0.44) CYP2C19SIGMAR1RAPGEF4
SCHEMBL13136832 0.95 CYP2C19 (0.44) CYP2C19SIGMAR1RAPGEF4
SCHEMBL17678530 0.93 BCL2 (0.46) BCL2SIGMAR1PTGS2NISCH
SCHEMBL1858399 0.92 BCL2 (0.41) BCL2CYP2C19SIGMAR1RAPGEF4PTGS2
SCHEMBL12798297 0.91 CYP2C19 (0.50) CYP2C19SIGMAR1RAPGEF4KDM4EALDH1A1
SCHEMBL14114271 0.89 BCL2 (0.44) BCL2SIGMAR1PTGS2NISCH
SCHEMBL1702238 0.89 SIGMAR1 (0.48) BCL2CYP2C19SIGMAR1PTGS2KDM4E
SCHEMBL4576079 0.89 SIGMAR1 (0.48) BCL2CYP2C19SIGMAR1PTGS2KDM4E
SCHEMBL10301479 0.89 SIGMAR1 (0.43) BCL2CYP2C19SIGMAR1PTGS2ALDH1A1
SCHEMBL12533849 0.88 BCL2 (0.50) BCL2CYP2C19SIGMAR1PTGS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11067909-B2 Terphenyl compound, electrophotographic photosensitive member, and method for producing terphenyl compound KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2021-07-20 US disclosed
US-11003101-B2 Electrophotographic photosensitive member, process cartridge, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2021-05-11 US disclosed
US-10996575-B2 Electrophotographic photosensitive member, process cartridge, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2021-05-04 US disclosed
US-20200233324-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-07-23 US disclosed
US-20200233323-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-07-23 US disclosed
US-20200231535-A1 TERPHENYL COMPOUND, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND METHOD FOR PRODUCING TERPHENYL COMPOUND KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2020-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11067909-B2 Terphenyl compound, electrophotographic photosensitive member, and method for producing terphenyl compound ABCB1, TERB1, PAH BCL2 3941/4885CYP2C19 101/4885SIGMAR1 3418/4885
US-20200231535-A1 TERPHENYL COMPOUND, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND METHOD FOR PRODUCING TERPHENYL COMPOUND ABCB1, TERB1, PAH BCL2 3941/4885CYP2C19 101/4885SIGMAR1 3418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.