SCHEMBL2224533

SCHEMBL2224533

CCOCOC(C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)Cn1cc([N+](=O)[O-])nc1Cl)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 4/20 0.35
CHRM1 P11229 1/20 0.32
PTGS1 P23219 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2224537 0.80
SCHEMBL2223253 0.77 ALDH1A1 (0.37) PKM
SCHEMBL2227515 0.77 CHRM1 (0.42) KCNH2CHRM1PTGS1SLC6A2SLC6A4
SCHEMBL28531245 0.71 CHRM1 (0.43) KCNH2CHRM1PTGS1SLC6A2SLC6A4
SCHEMBL28531244 0.71 CHRM1 (0.43) KCNH2CHRM1PTGS1SLC6A2SLC6A4
SCHEMBL2269228 0.68 PKM (0.33) PKM
SCHEMBL2224735 0.67 ALDH1A1 (0.38) PKM
SCHEMBL4777936 0.66 PTGS1 (0.42) KCNH2CHRM1PTGS1SLC6A2SLC6A4
SCHEMBL14004046 0.66 PKM (0.39) PKM
SCHEMBL1227126 0.65 KCNH2 (0.43) KCNH2CHRM1PTGS1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011087995-A2 ORGANIC COMPOUNDS BARRY CLIFTON (US) 2011-07-21 WO disclosed