Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 2/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207837 | 0.89 | SORD (0.46) | SORDGPR119DRD4AKT1PARP1 | |
| SCHEMBL9767811 | 0.87 | — | — | |
| SCHEMBL4453478 | 0.83 | SORD (0.56) | SORDGPR119DRD4AKT1PARP1 | |
| SCHEMBL30775404 | 0.83 | SORD (0.56) | SORDGPR119DRD4AKT1PARP1 | |
| SCHEMBL209844 | 0.82 | SORD (0.54) | SORDGPR119DRD4AKT1ROCK1 | |
| SCHEMBL209842 | 0.82 | SORD (0.54) | SORDGPR119DRD4AKT1ROCK1 | |
| SCHEMBL29611181 | 0.82 | SORD (0.54) | SORDGPR119DRD4AKT1ROCK1 | |
| SCHEMBL2103794 | 0.80 | SORD (0.53) | SORDGPR119DRD4AKT1PARP1 | |
| SCHEMBL30894880 | 0.79 | SORD (0.49) | SORDGPR119DRD4AKT1PARP1 | |
| SCHEMBL15863561 | 0.78 | PLD1 (0.59) | SORDDRD4PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931707-A1 | ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS | Glaxosmithkline LLC (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014107277-A1 | ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-07-10 | — | — | WO | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |